Tenali Junction is located in the Guntur district of Andhra Pradesh under the jurisdiction of South Central Railways. Station code is TEL.  It is a busy junction connected to Guntur, Vijayawada, Rapallie and Chennai along with cities of Gujarat, Orissa, Tamil Nadu, West Bengal, Karnataka, Kerala, Jammu, Uttar Pradesh, Bihar, Maharashtra, and Chhattisgarh. Guntur, which is at about 30 km from Tenali is the nearest railway station by road.
Tenali region is known as the rice bowl of Southern India. Cities approachable from Tenali are Vijayawada, Machalipatnam, Nagarjunakonda, and Amaravathi.  Many Express trains run through this station connecting Bhubaneswar, Tirupati, Shalimar, Nagarcoil, Chennai, Delhi, Ahmadabad, Shalimar, Hyderabad, Bangalore, Kanyakumari, Allepy etc. Himsagar Express, Navjeevan express, Charminar Express, Jan Shatabdhi, Sabari, Navyug are some of the major trains stopping at Tenali station.